sickle-cell+disease

__What is Sickle-cell disease?__ Sickle-cell disease is a blood disorder that causes your red blood cells to have a abnormal, rigid, sickle shape. It is a life-long illness. The cause of the sickle shaped red blood cells, is from mutation in the haemoglobin gene. The average life expectancy for people with Sickle-cell disease is 42 to 48 years. If someone has only one of the two alleles for Sickle-cell, they are more resistant to Malaria. That's why this disease occurs mostly where Malaria is common. __Who does Sickle-cell disease affect?__ Sickle-cell disease occurs most commonly in people who are from tropical or Sub-Saharan regions and their descendants. It also occurs where Malaria is common. In America, 1 in 500 black births are born with Sickle-cell. About 1 in 12 African Americans (2 million Americans) have the Sickle-cell trait, which means they do not have he but are carriers of it. __Signs, Symptoms and Complications__
 * Hand-foot Syndrome
 * Fatigue
 * Shortness of breath
 * Eye problems
 * Yellowing of skin and eyes
 * Delayed growth and puberty in children
 * Weak immune symptoms
 * Stroke
 * Acute Chest Syndrome
 * Ulcers
 * Bone pain
 * Abdominal pain